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Target
Rhodopsin kinase GRK7
Ligand
BDBM50309910
Substrate
n/a
Meas. Tech.
ChEMBL_774199 (CHEMBL1908416)
Kd
>10000±n/a nM
Citation
 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol 29:1046-51 (2011) [PubMed]  Article 
Target
Name:
Rhodopsin kinase GRK7
Synonyms:
G protein-coupled receptor kinase 7 | GPRK7 | GRK7 | GRK7_HUMAN
Type:
PROTEIN
Mol. Mass.:
62210.84
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774199
Residue:
553
Sequence:
MVDMGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLCEQQPIGRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPGNPQPFLSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELNDPNRPTGCEEGNSSKSGVCLLL
  
Inhibitor
Name:
BDBM50309910
Synonyms:
CHEMBL608154 | ML-120B | N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methylnicotinamide
Type:
Small organic molecule
Emp. Form.:
C19H15ClN4O2
Mol. Mass.:
366.801
SMILES:
COc1c(Cl)cc2c3ccncc3[nH]c2c1NC(=O)c1cccnc1C
Structure:
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