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Target
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Ligand
BDBM50356010
Substrate
n/a
Meas. Tech.
ChEMBL_775061 (CHEMBL1912256)
IC50
150±n/a nM
Citation
 Qian, Y; Ahmad, M; Chen, S; Gillespie, P; Le, N; Mennona, F; Mischke, S; So, SS; Wang, H; Burghardt, C; Tannu, S; Conde-Knape, K; Kochan, J; Bolin, D Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors. Bioorg Med Chem Lett 21:6264-9 (2011) [PubMed]  Article 
Target
Name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Synonyms:
GFAT | GFPT | GFPT1 | GFPT1_HUMAN | Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Type:
PROTEIN
Mol. Mass.:
78813.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_775079
Residue:
699
Sequence:
MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGFDGGNDKDWEANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNRESQDTSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSKFTRWGSQGERGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFLSQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE
  
Inhibitor
Name:
BDBM50356010
Synonyms:
CHEMBL1911372
Type:
Small organic molecule
Emp. Form.:
C5H9BrN2O3
Mol. Mass.:
225.041
SMILES:
N[C@@H](CNC(=O)CBr)C(O)=O |r|
Structure:
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