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Target
Small conductance calcium-activated potassium channel protein 2
Ligand
BDBM50356158
Substrate
n/a
Meas. Tech.
ChEMBL_776011 (CHEMBL1913009)
Ki
593±n/a nM
Citation
 Badarau, E; Dilly, S; Dufour, F; Poncin, S; Seutin, V; Liégeois, JF Synthesis and radioligand binding studies of bis-(8-isopropyl-isoquinolinium) derivatives as ligands for apamin-sensitive sites on cloned SK2 and SK3 channels. Bioorg Med Chem Lett 21:6756-9 (2011) [PubMed]  Article 
Target
Name:
Small conductance calcium-activated potassium channel protein 2
Synonyms:
KCNN2 | KCNN2_HUMAN | SK2
Type:
PROTEIN
Mol. Mass.:
63788.70
Organism:
Homo sapiens (Human)
Description:
ChEMBL_480083
Residue:
579
Sequence:
MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
  
Inhibitor
Name:
BDBM50356158
Synonyms:
CHEMBL1909928
Type:
Small organic molecule
Emp. Form.:
C29H36N2
Mol. Mass.:
412.6084
SMILES:
CC(C)c1cccc2cc[n+](C)c(CCCc3[n+](C)ccc4cccc(C(C)C)c34)c12
Structure:
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