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Target
Adenosine deaminase
Ligand
BDBM50356463
Substrate
n/a
Meas. Tech.
ChEMBL_775741 (CHEMBL1912098)
IC50
3700±n/a nM
Citation
 Zhang, HW; Zhou, L; Coats, SJ; McBrayer, TR; Tharnish, PM; Bondada, L; Detorio, M; Amichai, SA; Johns, MD; Whitaker, T; Schinazi, RF Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents. Bioorg Med Chem Lett 21:6788-92 (2011) [PubMed]  Article 
Target
Name:
Adenosine deaminase
Synonyms:
ADA | ADA1 | ADA_HUMAN | Adenosine aminohydrolase
Type:
Enzyme
Mol. Mass.:
40759.44
Organism:
Homo sapiens (Human)
Description:
Human recombinant ADA was expressed and purified from an ADA-deficient bacterial strain.
Residue:
363
Sequence:
MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAGQNL
  
Inhibitor
Name:
BDBM50356463
Synonyms:
CHEMBL1911841
Type:
Small organic molecule
Emp. Form.:
C13H16N8O4
Mol. Mass.:
348.3173
SMILES:
C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(N)nc(nc12)-n1ccnn1 |r|
Structure:
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