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Target
Histamine H3 receptor
Ligand
BDBM50357153
Substrate
n/a
Meas. Tech.
ChEMBL_787546 (CHEMBL1919507)
Ki
42±n/a nM
Citation
 Dandu, RR; Gruner, JA; Mathiasen, JR; Aimone, LD; Hostetler, G; Benfield, C; Bendesky, RJ; Marcy, VR; Raddatz, R; Hudkins, RL Synthesis and evaluation of pyridazinone-phenethylamine derivatives as selective and orally bioavailable histamine H3 receptor antagonists with robust wake-promoting activity. Bioorg Med Chem Lett 21:6362-5 (2011) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50357153
Synonyms:
CHEMBL1917467
Type:
Small organic molecule
Emp. Form.:
C23H25N3O
Mol. Mass.:
359.4641
SMILES:
C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(=O)n(n1)-c1ccccc1 |r|
Structure:
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