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Target
Prostacyclin receptor
Ligand
BDBM50351485
Substrate
n/a
Meas. Tech.
ChEMBL_788407 (CHEMBL1918135)
Ki
6400±n/a nM
Citation
 Iwahashi, M; Naganawa, A; Kinoshita, A; Shimabukuro, A; Nishiyama, T; Ogawa, S; Matsunaga, Y; Tsukamoto, K; Okada, Y; Matsumoto, R; Nambu, F; Oumi, R; Odagaki, Y; Katagi, J; Yano, K; Tani, K; Nakai, H; Toda, M Discovery of new orally active prostaglandin D2 receptor antagonists. Bioorg Med Chem 19:6935-48 (2011) [PubMed]  Article 
Target
Name:
Prostacyclin receptor
Synonyms:
PGI receptor | PI2R_HUMAN | PRIPR | PTGIR | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor | Prostanoid IP receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40968.22
Organism:
Homo sapiens (Human)
Description:
The membranes prepared from human platelet were used in binding assay.
Residue:
386
Sequence:
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
  
Inhibitor
Name:
BDBM50351485
Synonyms:
CHEMBL1819603
Type:
Small organic molecule
Emp. Form.:
C25H24N2O5
Mol. Mass.:
432.4685
SMILES:
CN1C[C@@H](COc2ccc(cc2)C(=O)Nc2cccc(CC(O)=O)c2)Oc2ccccc12 |r|
Structure:
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