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Target
Laccase
Ligand
BDBM50357700
Substrate
n/a
Meas. Tech.
ChEMBL_786154 (CHEMBL1919988)
IC50
4700±n/a nM
Citation
 Dalisay, DS; Saludes, JP; Molinski, TF Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans. Bioorg Med Chem 19:6654-7 (2011) [PubMed]  Article 
Target
Name:
Laccase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
55472.53
Organism:
Trametes versicolor
Description:
ChEMBL_786157
Residue:
520
Sequence:
MSRFHSLLAFVVASLAAVAHAGIGPVADLTITNAAVSPDGFSRQAVVVNGGTPGPLITGNMGDRFQLNVIDNLTDHTMLKSTSIHWHGFFQKGTNWADGPAFINQCPISSGHSFLYDFQVPDQAGTFWYHSHLSTQYCDGLRGPFVVYDPNDPAADLYDVDNDDTVITLADWYHVAAKLGPAFPLGADATLINGKGRSPSTTTADLTVISVTPGKRYRFRLVSLSCDPNHTFSIDGHNMTIIETDSINTAPLVVDSIQIFAAQRYSFVLEANQAVDNYWIRANPSFGNVGFTGGINSAILRYDGAAAIEPTTTQTTSTEPLNEVNLHPLVATAVPGSPAAGGVDLAINMAFNFNGTNFFINGASFTPPTVPVLLQIISGAQNAQDLLPSGSVYSLPSNADIEISFPATAAAPGAPHPFHLHGHAFAVVRSAGSTVYNYDNPIFRDVVSTGTPAAGDNVTIRFRTDNPGPWFLHCHIDFHLEAGFAVVFAEDIPDVASANPVPQAWSDLCPTYDARDPSDQ
  
Inhibitor
Name:
BDBM50357700
Synonyms:
PTILOMYCALIN A
Type:
Small organic molecule
Emp. Form.:
C45H83N6O5
Mol. Mass.:
788.1772
SMILES:
CC[C@H]1CCCC[C@@]2(C[C@@H]3CC[C@@H]4[C@H](C(=O)OCCCCCCCCCCCCCCCC(=O)N(CCCN)CCCCN)[C@]5(CCC[C@@H](C)O5)NC(N2)=[N+]34)O1 |r,t:55|
Structure:
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