Target
C-X-C chemokine receptor type 3
Ligand
BDBM50358617
Substrate
n/a
Meas. Tech.
ChEMBL_789428 (CHEMBL1924404)
IC50
0.3±n/a nM
Citation
 Kim, SHAnilkumar, GNZawacki, LGZeng, QYang, DYShao, YDong, GXu, XYu, WJiang, YJenh, CHHall, JWCarroll, CDHobbs, DWBaldwin, JJMcGuinness, BFRosenblum, SBKozlowski, JAShankar, BBShih, NY III. Identification of novel CXCR3 chemokine receptor antagonists with a pyrazinyl-piperazinyl-piperidine scaffold. Bioorg Med Chem Lett 21:6982-6 (2011) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 3
Synonyms:
AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3 | CXCR3A | CXCR3_HUMAN | GPR9 | chemokine (C-X-C motif) receptor 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40665.65
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
368
Sequence:
MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
  
Inhibitor
Name:
BDBM50358617
Synonyms:
CHEMBL1921866
Type:
Small organic molecule
Emp. Form.:
C26H37Cl2N7O2
Mol. Mass.:
550.524
SMILES:
CC[C@H]1CN(CCN1C1CCN(Cc2ccc(Cl)cc2)CC1)c1nc(N)c(nc1Cl)C(=O)NCC(C)O |r|
Structure:
Search PDB for entries with ligand similarity: