Ki Summary

Reaction Details

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Target

cAMP-specific 3',5'-cyclic phosphodiesterase 4D

Ligand

BDBM50358828

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_790392

IC50

22±n/a nM

Citation

Nankervis, JL; Feil, SC; Hancock, NC; Zheng, Z; Ng, HL; Morton, CJ; Holien, JK; Ho, PW; Frazzetto, MM; Jennings, IG; Manallack, DT; Martin, TJ; Thompson, PE; Parker, MW Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2. Bioorg Med Chem Lett21:7089-93 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

cAMP-specific 3',5'-cyclic phosphodiesterase 4D

Name:

3',5'-cyclic phosphodiesterase

Synonyms:

DPDE3 | PDE43 | PDE4D | Phosphodiesterase 4D

Type:

Protein

Mol. Mass.:

91092.69

Organism:

Homo sapiens (Human)

Description:

Q08499

Residue:

809

Sequence:

MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPP
PPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRA
MDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQA
NFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNF
AALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSV
SEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRP
MSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPL
TVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST
PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGF
KLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVL
LLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMC
DKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAP
DDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPL
DEQVEEEAVGEEEESQPEACVIDDRSPDT

BDBM50358828

Name

BDBM50358828

Synonyms:

CHEMBL1922946

Type

Small organic molecule

Emp. Form.

C19H22N2O5S2

Mol. Mass.

422.518

SMILES

CCOC(=O)N1CCc2c(C1)sc(NC(=O)Cc1cccs1)c2C(=O)OCC

Structure

n/a