Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50359032
Substrate
n/a
Meas. Tech.
ChEMBL_791037 (CHEMBL1925747)
Kd
251.19±n/a nM
Citation
 Wang, GZ; Haile, PA; Daniel, T; Belot, B; Viet, AQ; Goodman, KB; Sha, D; Dowdell, SE; Varga, N; Hong, X; Chakravorty, S; Webb, C; Cornejo, C; Olzinski, A; Bernard, R; Evans, C; Emmons, A; Briand, J; Chung, CW; Quek, R; Lee, D; Gough, PJ; Sehon, CA CCR2 receptor antagonists: optimization of biaryl sulfonamides to increase activity in whole blood. Bioorg Med Chem Lett 21:7291-4 (2011) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50359032
Synonyms:
CHEMBL1924024
Type:
Small organic molecule
Emp. Form.:
C27H26Cl2F3N3O5S
Mol. Mass.:
632.479
SMILES:
COc1cc(ccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(c1)C(F)(F)F)C(=O)NCCN1CCCC1
Structure:
Search PDB for entries with ligand similarity: