Reaction Details Report a problem with these data
Target
Cell division protein FtsZ
Ligand
BDBM50359410
Substrate
n/a
Meas. Tech.
ChEMBL_793371 (CHEMBL1931925)
IC50
27300±n/a nM
Citation
 Mathew, B; Srivastava, S; Ross, LJ; Suling, WJ; White, EL; Woolhiser, LK; Lenaerts, AJ; Reynolds, RC Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors. Bioorg Med Chem 19:7120-8 (2011) [PubMed]  Article 
Target
Name:
Cell division protein FtsZ
Synonyms:
FTSZ_MYCTU | ftsZ
Type:
PROTEIN
Mol. Mass.:
38736.30
Organism:
Mycobacterium tuberculosis
Description:
ChEMBL_1470459
Residue:
379
Sequence:
MTPPHNYLAVIKVVGIGGGGVNAVNRMIEQGLKGVEFIAINTDAQALLMSDADVKLDVGRDSTRGLGAGADPEVGRKAAEDAKDEIEELLRGADMVFVTAGEGGGTGTGGAPVVASIARKLGALTVGVVTRPFSFEGKRRSNQAENGIAALRESCDTLIVIPNDRLLQMGDAAVSLMDAFRSADEVLLNGVQGITDLITTPGLINVDFADVKGIMSGAGTALMGIGSARGEGRSLKAAEIAINSPLLEASMEGAQGVLMSIAGGSDLGLFEINEAASLVQDAAHPDANIIFGTVIDDSLGDEVRVTVIAAGFDVSGPGRKPVMGETGGAHRIESAKAGKLTSTLFEPVDAVSVPLHTNGATLSIGGDDDDVDVPPFMRR
  
Inhibitor
Name:
BDBM50359410
Synonyms:
CHEMBL1926722
Type:
Small organic molecule
Emp. Form.:
C22H24N6O2S2
Mol. Mass.:
468.595
SMILES:
CCOC(=O)Nc1cc(NCCN(C)C)c2nc(-c3cccs3)c(nc2n1)-c1cccs1
Structure:
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