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Target
NADPH oxidase 4
Ligand
BDBM50359522
Substrate
n/a
Meas. Tech.
ChEMBL_792879 (CHEMBL1931064)
Ki
156±n/a nM
Citation
 Gaggini, F; Laleu, B; Orchard, M; Fioraso-Cartier, L; Cagnon, L; Houngninou-Molango, S; Gradia, A; Duboux, G; Merlot, C; Heitz, F; Szyndralewiez, C; Page, P Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors. Bioorg Med Chem 19:6989-99 (2011) [PubMed]  Article 
Target
Name:
NADPH oxidase 4
Synonyms:
KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | NOX4_HUMAN | RENOX | Renal NAD(P)H-oxidase
Type:
PROTEIN
Mol. Mass.:
66954.54
Organism:
Homo sapiens (Human)
Description:
ChEMBL_792879
Residue:
578
Sequence:
MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRASASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHVAAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTYAIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLPEYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLYRYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLHNKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGKTVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
  
Inhibitor
Name:
BDBM50359522
Synonyms:
CHEMBL1927160
Type:
Small organic molecule
Emp. Form.:
C15H12ClN3O3
Mol. Mass.:
317.727
SMILES:
Clc1ccccc1-n1[nH]c2cc(=O)n3CCOCc3c2c1=O
Structure:
Search PDB for entries with ligand similarity: