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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50359615
Substrate
n/a
Meas. Tech.
ChEMBL_793158 (CHEMBL1931472)
EC50
2.6±n/a nM
Citation
 Hayashi, R; Hosono, Y; Nakatsuji, K; Tanaka, Y; Mori, T; Kanno, T; Makita, K; Moriwaki, M; Ohyama, T; Ochi, Y; Inada, C; Isogaya, M Efficient synthesis of a novel m-phenylene derivative as a selective EP4 agonist inducing follicular growth and maturation in the ovary. Bioorg Med Chem Lett 21:7505-8 (2011) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_RABIT | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER4 | Prostanoid EP4 receptor
Type:
PROTEIN
Mol. Mass.:
53381.06
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_793158
Residue:
488
Sequence:
MSTPVANASASSMPELLNNPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSRLQFPDTWCFIDWRTNVTAHAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAAAVTSAACRGHPTASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPDLVREISQNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRDRSGQHCSDSRRTSSAMSTHSRSFLSRELKEISSTSQTLLYLPELSENSLAGRNLLPGVPLVGLAQADTTSLRTWRGSETSDSSQGQDSESVLLVDEVGGGGRAGPTPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM50359615
Synonyms:
CHEMBL1928220
Type:
Small organic molecule
Emp. Form.:
C24H32N4O3
Mol. Mass.:
424.5359
SMILES:
O[C@@H](CC1CCCCC1)\C=C\[C@H]1[C@H](O)C[C@@H]2Oc3c(cccc3CCc3nnn[nH]3)[C@H]12 |r|
Structure:
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