Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50359808
Substrate
n/a
Meas. Tech.
ChEMBL_791990 (CHEMBL1930050)
IC50
51±n/a nM
Citation
 Reader, JCMatthews, TPKlair, SCheung, KMScanlon, JProisy, NAddison, GEllard, JPiton, NTaylor, SCherry, MFisher, MBoxall, KBurns, SWalton, MIWestwood, IMHayes, AEve, PValenti, Mde Haven Brandon, ABox, Gvan Montfort, RLWilliams, DHAherne, GWRaynaud, FIEccles, SAGarrett, MDCollins, I Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing. J Med Chem 54:8328-42 (2011) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50359808
Synonyms:
CHEMBL1928703
Type:
Small organic molecule
Emp. Form.:
C19H20N6O
Mol. Mass.:
348.4017
SMILES:
CC(CN(C)C)Oc1nc(Nc2cc3ccccc3cn2)cnc1C#N
Structure:
Search PDB for entries with ligand similarity: