Reaction Details
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Histone acetyltransferase KAT8
Ligand
BDBM50292429
Substrate
n/a
Meas. Tech.
ChEMBL_796800 (CHEMBL1938115)
IC50
43000±n/a nM
Citation
Ghizzoni, M; Wu, J; Gao, T; Haisma, HJ; Dekker, FJ; George Zheng, Y 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site. Eur J Med Chem 47:337-44 (2012) [PubMed] Article More Info.:
Target
Name:
Histone acetyltransferase KAT8
Synonyms:
KAT8 | KAT8_HUMAN | Lysine acetyltransferase 8 | MOF | MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1 | MYST-1 | MYST1 | hMOF
Type:
PROTEIN
Mol. Mass.:
52413.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_796800
Residue:
458
Sequence:
MAAQGAAAAVAAGTSGVAGEGEPGPGENAAAEGTAPSPGRVSPPTPARGEPEVTVEIGETYLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQKNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAPPKHKQVKLSKK
Inhibitor
Name:
BDBM50292429
Synonyms:
2-Hydroxy-6-pentadecyl-benzoic acid | 2-Pentadecyl-6-hydroxybenzoic acid | 2-hydroxy-6-((8Z,11Z)-pentadeca-8,11,14-trienyl)benzoic acid | 2-hydroxy-6-pentadecylbenzoic acid | 6-[8(Z),11(Z),14-pentadecatrienyl]salicylic acid | 6-pentadecatrienylsalicylic acid | 6-pentadecylsalicylic acid | 6-{8(Z),11(Z),14-pentadecatrienyl}salicylic acid | 6[8'(Z ),11'(Z ),14'-pentadecatrienyl]salicylicacid | BPH-953 | CHEMBL455368 | anacardic acid
Type:
Small organic molecule
Emp. Form.:
C22H30O3
Mol. Mass.:
342.4718
SMILES:
OC(=O)c1c(O)cccc1CCCCCCC\C=C/C\C=C/CC=C
Structure:
