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TargetGlucagon receptor
LigandBDBM50360596
Substrate/Competitorn/a
Meas. Tech.ChEMBL_795440
Ki 1450±n/a nM
Citation Filipski, KJBian, JEbner, DCLee, ECLi, JCSammons, MFWright, SWStevens, BDDidiuk, MTTu, MPerreault, CBrown, JAtkinson, KTan, BSalatto, CTLitchfield, JPfefferkorn, JAGuzman-Perez, A A novel series of glucagon receptor antagonists with reduced molecular weight and lipophilicity. Bioorg Med Chem Lett22:415-20 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glucagon receptor
Name:Glucagon receptor
Synonyms:GL-R | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:Enzyme
Mol. Mass.:54026.92
Organism:Homo sapiens (Human)
Description:P47871
Residue:477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR
TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ
CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL
FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC
WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN
MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV
HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL
GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50360596
NameBDBM50360596
Synonyms:CHEMBL1933362
TypeSmall organic molecule
Emp. Form.C23H23F3N4O4
Mol. Mass.476.4483
SMILESCCCC(Oc1cnn(c1)-c1ccc(nc1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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