Reaction Details Report a problem with these data
Target
Gastric inhibitory polypeptide receptor
Ligand
BDBM50360594
Substrate
n/a
Meas. Tech.
ChEMBL_795449 (CHEMBL1937454)
Ki
4080±n/a nM
Citation
 Filipski, KJ; Bian, J; Ebner, DC; Lee, EC; Li, JC; Sammons, MF; Wright, SW; Stevens, BD; Didiuk, MT; Tu, M; Perreault, C; Brown, J; Atkinson, K; Tan, B; Salatto, CT; Litchfield, J; Pfefferkorn, JA; Guzman-Perez, A A novel series of glucagon receptor antagonists with reduced molecular weight and lipophilicity. Bioorg Med Chem Lett 22:415-20 (2011) [PubMed]  Article 
Target
Name:
Gastric inhibitory polypeptide receptor
Synonyms:
GIPR | GIPR_HUMAN | Gastric Inhibitory Polypeptide Receptor (GIPR) | Gastric inhibitory polypeptide receptor
Type:
PROTEIN
Mol. Mass.:
53173.82
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1518286
Residue:
466
Sequence:
MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
  
Inhibitor
Name:
BDBM50360594
Synonyms:
CHEMBL1933360
Type:
Small organic molecule
Emp. Form.:
C24H24F3N3O4
Mol. Mass.:
475.4603
SMILES:
CCCC(Oc1cnn(c1)-c1ccc(cc1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Structure:
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