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Target
Cytochrome P450 2D6
Ligand
BDBM50360902
Substrate
n/a
Meas. Tech.
ChEMBL_795482 (CHEMBL1937487)
IC50
>30000±n/a nM
Citation
 Hudkins, RL; Aimone, LD; Dandu, RR; Dunn, D; Gruner, JA; Huang, Z; Josef, KA; Lyons, JA; Mathiasen, JR; Tao, M; Zulli, AL; Raddatz, R 4,5-dihydropyridazin-3-one derivatives as histamine H3 receptor inverse agonists. Bioorg Med Chem Lett 22:194-8 (2011) [PubMed]  Article 
Target
Name:
Cytochrome P450 2D6
Synonyms:
CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:
Protein
Mol. Mass.:
55774.82
Organism:
Homo sapiens (Human)
Description:
P10635
Residue:
497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
  
Inhibitor
Name:
BDBM50360902
Synonyms:
CHEMBL1935114
Type:
Small organic molecule
Emp. Form.:
C20H29N3O2
Mol. Mass.:
343.4632
SMILES:
C[C@@H]1CCCN1CCCOc1ccc(cc1)C1=NNC(=O)C(C)(C)C1 |r,t:18|
Structure:
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