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TargetMacrophage metalloelastase
LigandBDBM50360969
Substrate/Competitorn/a
Meas. Tech.ChEMBL_796156
IC50 57±n/a nM
Citation Wu, YLi, JWu, JMorgan, PXu, XRancati, FVallese, SRaveglia, LHotchandani, RFuller, NBard, JCunningham, KFish, SKrykbaev, RTam, SGoldman, SJWilliams, CMansour, TSSaiah, ESypek, JLi, W Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD). Bioorg Med Chem Lett22:138-43 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Macrophage metalloelastase
Name:Macrophage metalloelastase
Synonyms:MME | MMP-12 | Matrix metalloproteinase-12
Type:PROTEIN
Mol. Mass.:53594.75
Organism:Oryctolagus cuniculus
Description:ChEMBL_796156
Residue:464
Sequence:
MKFLLLILTLWVTSSGADPLKENDMLFAENYLENFYGLKVERIPMTKMKTNRNFIEEKVQ
EMQQFLGLNVTGQLDTSTLEMMHKPRCGVPDVYHFKTMPGRPVWRKHYITYRIKNYTPDM
KREDVEYAIQKAFQVWSDVTPLKFRKITTGKADIMILFASGAHGDYGAFDGRGGVIAHAF
GPGPGIGGDTHFDEDEIWSKSYKGTNLFLVAVHELGHALGLDHSNDPKAIMFPTYGYIDL
NTFHLSADDIRGIQSLYGGPEQHQPMPKPDNPEPTACDHNLKFDAVTTVGNKIFFFKDSF
FWWKIPKSSTTSVRLISSLWPTLPSGIEAAYEIGDRHQVFLFKGDKFWLISHLRLQPNYP
KSIHSLGFPDFVKKIDAAVFNPSLRKTYFFVDNLYWRYDERREVMDAGYPKLITKHFPGI
GPKIDAVFYFQRYYYFFQGPNQLEYDTFSSRVTKKLKSNSWFDC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50360969
NameBDBM50360969
Synonyms:CHEMBL1935291
TypeSmall organic molecule
Emp. Form.C20H18N2O5S2
Mol. Mass.430.497
SMILESCC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)-c1nccs1)C(O)=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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