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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50361049
Substrate
n/a
Meas. Tech.
ChEMBL_796062 (CHEMBL1936932)
IC50
34±n/a nM
Citation
 Sundar, BG; Bailey, TR; Dunn, DD; Bacon, ER; Salvino, JM; Morton, GC; Aimone, LD; Zeqi, H; Mathiasen, JR; Dicamillo, A; Huffman, MJ; McKenna, BA; Kopec, K; Lu, LD; Brown, R; Qian, J; Angeles, T; Connors, T; Spais, C; Holskin, B; Galinis, D; Duzic, E; Schaffhauser, H; Rosse, GC Novel brain penetrant benzofuropiperidine 5-HT6 receptor antagonists. Bioorg Med Chem Lett 22:120-3 (2011) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50361049
Synonyms:
CHEMBL1935593
Type:
Small organic molecule
Emp. Form.:
C19H19NO3S
Mol. Mass.:
341.424
SMILES:
CC1(C)NCCc2c1oc1cc(ccc21)S(=O)(=O)c1ccccc1
Structure:
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