Reaction Details Report a problem with these data
Target
Natural resistance-associated macrophage protein 2
Ligand
BDBM50361105
Substrate
n/a
Meas. Tech.
ChEMBL_795244 (CHEMBL1936903)
IC50
150±n/a nM
Citation
 Cadieux, JA; Zhang, Z; Mattice, M; Brownlie-Cutts, A; Fu, J; Ratkay, LG; Kwan, R; Thompson, J; Sanghara, J; Zhong, J; Goldberg, YP Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1). Bioorg Med Chem Lett 22:90-5 (2011) [PubMed]  Article 
Target
Name:
Natural resistance-associated macrophage protein 2
Synonyms:
DCT1 | DMT-1 | DMT1 | Divalent cation transporter 1 | Divalent metal transporter 1 | NRAM2_HUMAN | NRAMP 2 | NRAMP2 | SLC11A2
Type:
PROTEIN
Mol. Mass.:
62262.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_795244
Residue:
568
Sequence:
MVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAGGILVLIICSINMYFVVVYVRDLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDCGHTCHLGLTAQPELYLLNTMDADSLVSR
  
Inhibitor
Name:
BDBM50361105
Synonyms:
CHEMBL1933782
Type:
Small organic molecule
Emp. Form.:
C19H15N3OS
Mol. Mass.:
333.407
SMILES:
Cc1ccc2nc(sc2c1)-n1[nH]c2CCc3ccccc3-c2c1=O
Structure:
Search PDB for entries with ligand similarity: