Reaction Details Report a problem with these data
Target
Bone morphogenetic protein receptor type-1B
Ligand
BDBM50361269
Substrate
n/a
Meas. Tech.
ChEMBL_794624 (CHEMBL1937144)
Kd
11500±n/a nM
Citation
 Shelton, JR; Cutler, CE; Oliveira, M; Balzarini, J; Peterson, MA Synthesis, SAR, and preliminary mechanistic evaluation of novel antiproliferative N¿?¿,5'-bis-ureido- and 5'-carbamoyl-N¿?¿-ureidoadenosine derivatives. Bioorg Med Chem 20:1008-19 (2012) [PubMed]  Article 
Target
Name:
Bone morphogenetic protein receptor type-1B
Synonyms:
ALK-6 | ALK6 | BMPR1B | BMR1B_HUMAN | Bone morphogenetic protein receptor type-1B (BMPR1B)
Type:
Enzyme
Mol. Mass.:
56939.41
Organism:
Homo sapiens (Human)
Description:
O00238
Residue:
502
Sequence:
MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL
  
Inhibitor
Name:
BDBM50361269
Synonyms:
CHEMBL1079596
Type:
Small organic molecule
Emp. Form.:
C19H22N8O5
Mol. Mass.:
442.4286
SMILES:
CNC(=O)NC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC(=O)Nc3ccccc3)ncnc12 |r|
Structure:
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