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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50361352
Substrate
n/a
Meas. Tech.
ChEMBL_795136 (CHEMBL1936608)
EC50
>10000±n/a nM
Citation
 Rikimaru, K; Wakabayashi, T; Abe, H; Imoto, H; Maekawa, T; Ujikawa, O; Murase, K; Matsuo, T; Matsumoto, M; Nomura, C; Tsuge, H; Arimura, N; Kawakami, K; Sakamoto, J; Funami, M; Mol, CD; Snell, GP; Bragstad, KA; Sang, BC; Dougan, DR; Tanaka, T; Katayama, N; Horiguchi, Y; Momose, Y A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR)¿ agonists: design and synthesis of benzylpyrazole acylsulfonamides. Bioorg Med Chem 20:714-33 (2012) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50361352
Synonyms:
CHEMBL1933826
Type:
Small organic molecule
Emp. Form.:
C22H29Cl2N3O4S
Mol. Mass.:
502.454
SMILES:
CC(C)Oc1cc(CCC(=O)NS(=O)(=O)C2CCCCC2)n(Cc2ccc(Cl)cc2Cl)n1
Structure:
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