Target
Pyruvate kinase PKM
Ligand
BDBM50361553
Substrate
n/a
Meas. Tech.
ChEMBL_797232 (CHEMBL1942547)
EC50
>20000±n/a nM
Citation
 Walsh, MJBrimacombe, KRVeith, HBougie, JMDaniel, TLeister, WCantley, LCIsraelsen, WJVander Heiden, MGShen, MAuld, DSThomas, CJBoxer, MB 2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg Med Chem Lett 21:6322-7 (2011) [PubMed]  Article 
Target
Name:
Pyruvate kinase PKM
Synonyms:
KPYM_HUMAN | OIP3 | PK2 | PK3 | PKM | PKM2 | Pyruvate kinase (PKM2)
Type:
Protein
Mol. Mass.:
57944.31
Organism:
Homo sapiens (Human)
Description:
P14618
Residue:
531
Sequence:
MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
  
Inhibitor
Name:
BDBM50361553
Synonyms:
CHEMBL1938902
Type:
Small organic molecule
Emp. Form.:
C15H15NO4S
Mol. Mass.:
305.349
SMILES:
Cc1ccc(NS(=O)(=O)c2cccc(c2)C(O)=O)cc1C
Structure:
Search PDB for entries with ligand similarity: