Reaction Details Report a problem with these data
Target
Glutathione S-transferase A2
Ligand
BDBM50361793
Substrate
n/a
Meas. Tech.
ChEMBL_799590 (CHEMBL1941296)
IC50
77600±n/a nM
Citation
 Wang, CH; Wu, HT; Cheng, HM; Yen, TJ; Lu, IH; Chang, HC; Jao, SC; Shing, TK; Li, WS Inhibition of glutathione S-transferase M1 by new gabosine analogues is essential for overcoming cisplatin resistance in lung cancer cells. J Med Chem 54:8574-81 (2011) [PubMed]  Article 
Target
Name:
Glutathione S-transferase A2
Synonyms:
GST class-alpha member 2 | GST-gamma | GST2 | GSTA2 | GSTA2-2 | GSTA2_HUMAN | GTH2 | HA subunit 2
Type:
PROTEIN
Mol. Mass.:
25667.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_799590
Residue:
222
Sequence:
MAEKPKLHYSNIRGRMESIRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDIKEKALIDMYIEGIADLGEMILLLPFSQPEEQDAKLALIQEKTKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEESRKIFRF
  
Inhibitor
Name:
BDBM50361793
Synonyms:
CHEMBL1938634
Type:
Small organic molecule
Emp. Form.:
C26H30O8
Mol. Mass.:
470.5116
SMILES:
CO[C@]1(C)O[C@H]2[C@@H](OCc3ccc4ccccc4c3)C=C(COC(C)=O)C(=O)[C@@H]2O[C@@]1(C)OC |r,t:21|
Structure:
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