Reaction Details Report a problem with these data
Target
Receptor-type tyrosine-protein kinase FLT3
Ligand
BDBM50361916
Substrate
n/a
Meas. Tech.
ChEMBL_800033 (CHEMBL1941739)
IC50
3100±n/a nM
Citation
 Irie, T; Fujii, I; Sawa, M Design and combinatorial synthesis of a novel kinase-focused library using click chemistry-based fragment assembly. Bioorg Med Chem Lett 22:591-6 (2011) [PubMed]  Article 
Target
Name:
Receptor-type tyrosine-protein kinase FLT3
Synonyms:
CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1
Type:
Enzyme
Mol. Mass.:
112888.62
Organism:
Homo sapiens (Human)
Description:
P36888
Residue:
993
Sequence:
MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
  
Inhibitor
Name:
BDBM50361916
Synonyms:
CHEMBL1938966
Type:
Small organic molecule
Emp. Form.:
C20H21N5
Mol. Mass.:
331.4142
SMILES:
C1C2CC3CC1CC(C2)C3n1nncc1-c1ccc2nccnc2c1 |TLB:0:1:9:6.5.4,0:5:9:2.8.1,8:7:4:2.1.0,THB:10:9:4:2.1.0,8:1:9.7.6:4,(9.62,-8.52,;9.68,-9.96,;8.21,-10.42,;6.75,-9.94,;6.75,-8.42,;8.22,-7.95,;7.18,-9.08,;7.12,-10.63,;8.57,-11.14,;5.66,-11.17,;4.29,-11.88,;4.33,-13.43,;2.91,-13.94,;1.96,-12.72,;2.84,-11.45,;2.41,-9.96,;3.23,-8.65,;2.5,-7.3,;.96,-7.25,;.23,-5.89,;-1.31,-5.85,;-2.12,-7.17,;-1.39,-8.52,;.15,-8.56,;.87,-9.91,)|
Structure:
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