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Target
Neuropeptides B/W receptor type 1
Ligand
BDBM50362411
Substrate
n/a
Meas. Tech.
ChEMBL_797950 (CHEMBL1942827)
IC50
2.2±n/a nM
Citation
 Anthony Romero, F; Hastings, NB; Moningka, R; Guo, Z; Wang, M; Di Salvo, J; Lei, Y; Trusca, D; Deng, Q; Tong, V; Terebetski, JL; Ball, RG; Ujjainwalla, F The discovery of potent antagonists of NPBWR1 (GPR7). Bioorg Med Chem Lett 22:1014-8 (2012) [PubMed]  Article 
Target
Name:
Neuropeptides B/W receptor type 1
Synonyms:
G-protein coupled receptor 7 | Gpr7 | NPBW1_MOUSE | Npbwr1
Type:
PROTEIN
Mol. Mass.:
36085.77
Organism:
Mus musculus
Description:
ChEMBL_797950
Residue:
329
Sequence:
MHNLTLFESGGDNVSCGGSSLGCPNGSSLAPLPLPQPLAVAVPVVYGVICAVGLAGNSAVLYVLLRTPRMKTVTNVFILNLAIADELFTLVLPINIADFLLRRWPFGEVMCKLIVAVDQYNTFSSLYFLAVMSADRYLVVLATAESRRVSGRTYGAARAVSLAVWALVTLVVLPFAVFARLDEEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVTTICALYTTLLCRLRAIQLDSHAKALDRAKKRVTLLVAAILAVCLLCWTPYHLSTIVALTTDLPQTPLVIGISYFITSLSYANSCLNPFLYAFLDDSFRRSLRQLVSCRSA
  
Inhibitor
Name:
BDBM50362411
Synonyms:
CHEMBL1940541
Type:
Small organic molecule
Emp. Form.:
C29H34F3N5O2S2
Mol. Mass.:
605.738
SMILES:
COc1ccc(cc1)C1(CCC1)N[C@@H]1CC[C@@H]([C@H](C1)c1ccsc1)C(=O)N1CCN(CC1)c1nnc(s1)C(F)(F)F |r|
Structure:
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