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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50362954
Substrate
n/a
Meas. Tech.
ChEMBL_801283 (CHEMBL1947832)
EC50
60±n/a nM
Citation
 Liu, W; Lau, F; Liu, K; Wood, HB; Zhou, G; Chen, Y; Li, Y; Akiyama, TE; Castriota, G; Einstein, M; Wang, C; McCann, ME; Doebber, TW; Wu, M; Chang, CH; McNamara, L; McKeever, B; Mosley, RT; Berger, JP; Meinke, PT Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor¿ (PPAR¿) modulators. J Med Chem 54:8541-54 (2011) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50362954
Synonyms:
CHEMBL1947144
Type:
Small organic molecule
Emp. Form.:
C26H20N4O6
Mol. Mass.:
484.4602
SMILES:
COc1ccc2c(noc2c1)-n1c2ccccc2n(Cc2cccc(c2)[C@@]2(C)OC(O)=NC2=O)c1=O |r,wD:26.30,c:34,(3.67,-28.22,;2.34,-27.43,;1,-28.18,;.98,-29.73,;-.38,-30.48,;-1.7,-29.68,;-3.16,-30.12,;-4.05,-28.86,;-3.12,-27.63,;-1.67,-28.13,;-.32,-27.39,;-3.94,-31.44,;-5.41,-31.91,;-6.74,-31.13,;-8.08,-31.89,;-8.1,-33.43,;-6.77,-34.22,;-5.42,-33.45,;-3.96,-33.94,;-3.95,-35.48,;-2.61,-36.24,;-2.62,-37.78,;-1.28,-38.54,;.05,-37.77,;.04,-36.22,;-1.3,-35.46,;1.36,-35.44,;1.35,-36.98,;1.37,-33.9,;2.84,-33.43,;3.32,-31.97,;3.73,-34.68,;2.82,-35.92,;3.29,-37.39,;-3.04,-32.7,;-1.5,-32.71,)|
Structure:
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