Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50362957
Substrate
n/a
Meas. Tech.
ChEMBL_801272 (CHEMBL1947821)
EC50
83±n/a nM
Citation
Liu, W; Lau, F; Liu, K; Wood, HB; Zhou, G; Chen, Y; Li, Y; Akiyama, TE; Castriota, G; Einstein, M; Wang, C; McCann, ME; Doebber, TW; Wu, M; Chang, CH; McNamara, L; McKeever, B; Mosley, RT; Berger, JP; Meinke, PT Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor¿ (PPAR¿) modulators. J Med Chem 54:8541-54 (2011) [PubMed] Article
More Info.:
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
Inhibitor
Name:
BDBM50362957
Synonyms:
CHEMBL1946757
Type:
Small organic molecule
Emp. Form.:
C26H19ClF3N3O6
Mol. Mass.:
561.894
SMILES:
COc1ccc2c(noc2c1)-n1c2cc(ccc2n(Cc2ccc(Cl)c(O[C@H](C)C(O)=O)c2)c1=O)C(F)(F)F |r,wU:27.30,(3.39,4.69,;2.06,5.47,;.72,4.7,;.72,3.15,;-.63,2.39,;-1.96,3.17,;-3.42,2.72,;-4.32,3.96,;-3.41,5.2,;-1.95,4.71,;-.61,5.48,;-4.18,1.38,;-5.65,.89,;-6.98,1.66,;-8.31,.89,;-8.31,-.66,;-6.98,-1.43,;-5.64,-.65,;-4.17,-1.12,;-4.14,-2.66,;-2.8,-3.41,;-2.78,-4.94,;-1.43,-5.69,;-.11,-4.9,;1.24,-5.64,;-.14,-3.35,;1.17,-2.55,;2.52,-3.3,;2.55,-4.84,;3.84,-2.5,;5.19,-3.24,;3.81,-.96,;-1.49,-2.61,;-3.27,.14,;-1.73,.15,;-9.64,1.66,;-9.64,3.2,;-10.97,.89,;-10.8,2.43,)|