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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50362965
Substrate
n/a
Meas. Tech.
ChEMBL_801272 (CHEMBL1947821)
EC50
237±n/a nM
Citation
 Liu, W; Lau, F; Liu, K; Wood, HB; Zhou, G; Chen, Y; Li, Y; Akiyama, TE; Castriota, G; Einstein, M; Wang, C; McCann, ME; Doebber, TW; Wu, M; Chang, CH; McNamara, L; McKeever, B; Mosley, RT; Berger, JP; Meinke, PT Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor¿ (PPAR¿) modulators. J Med Chem 54:8541-54 (2011) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50362965
Synonyms:
CHEMBL1947140
Type:
Small organic molecule
Emp. Form.:
C27H19F3N4O6
Mol. Mass.:
552.4582
SMILES:
COc1ccc2c(noc2c1)-n1c2ccc(cc2n(Cc2cccc(c2)[C@@]2(C)OC(O)=NC2=O)c1=O)C(F)(F)F |r,wD:26.30,c:34,(4.48,3.56,;3.15,4.35,;1.81,3.6,;1.78,2.05,;.43,1.3,;-.89,2.1,;-2.35,1.66,;-3.24,2.92,;-2.31,4.15,;-.86,3.65,;.49,4.39,;-3.13,.34,;-4.6,-.13,;-5.93,.65,;-7.27,-.11,;-7.29,-1.65,;-5.96,-2.44,;-4.61,-1.67,;-3.15,-2.16,;-3.14,-3.7,;-1.81,-4.46,;-1.81,-6,;-.47,-6.76,;.86,-5.99,;.85,-4.44,;-.49,-3.68,;2.17,-3.66,;2.15,-5.2,;2.18,-2.12,;3.64,-1.65,;4.13,-.19,;4.54,-2.9,;3.63,-4.14,;4.1,-5.61,;-2.23,-.92,;-.69,-.93,;-8.63,-2.4,;-9.95,-1.62,;-8.65,-3.94,;-9.98,-3.14,)|
Structure:
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