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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50362968
Substrate
n/a
Meas. Tech.
ChEMBL_801272 (CHEMBL1947821)
EC50
102±n/a nM
Citation
 Liu, W; Lau, F; Liu, K; Wood, HB; Zhou, G; Chen, Y; Li, Y; Akiyama, TE; Castriota, G; Einstein, M; Wang, C; McCann, ME; Doebber, TW; Wu, M; Chang, CH; McNamara, L; McKeever, B; Mosley, RT; Berger, JP; Meinke, PT Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor¿ (PPAR¿) modulators. J Med Chem 54:8541-54 (2011) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50362968
Synonyms:
CHEMBL1947145
Type:
Small organic molecule
Emp. Form.:
C25H17ClN4O5
Mol. Mass.:
488.879
SMILES:
C[C@@]1(OC(O)=NC1=O)c1cccc(Cn2c3ccccc3n(-c3noc4cc(Cl)ccc34)c2=O)c1 |r,wD:1.0,c:4,(23.71,-37.27,;23.73,-35.74,;23.74,-34.2,;25.2,-33.73,;25.69,-32.27,;26.1,-34.98,;25.19,-36.22,;25.66,-37.69,;22.41,-36.51,;22.42,-38.06,;21.09,-38.84,;19.75,-38.08,;19.75,-36.54,;18.42,-35.77,;18.41,-34.23,;16.95,-33.75,;15.6,-34.51,;14.27,-33.72,;14.29,-32.18,;15.63,-31.43,;16.96,-32.21,;18.43,-31.74,;19.21,-30.41,;18.32,-29.16,;19.25,-27.93,;20.7,-28.43,;22.05,-27.68,;23.37,-28.47,;24.71,-27.72,;23.34,-30.03,;21.99,-30.77,;20.67,-29.98,;19.33,-32.99,;20.87,-33,;21.07,-35.76,)|
Structure:
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