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Target
Aldo-keto reductase family 1 member B10
Ligand
BDBM50363056
Substrate
n/a
Meas. Tech.
ChEMBL_800765 (CHEMBL1948101)
IC50
1600±n/a nM
Citation
 Minehira, D; Takeda, D; Urata, H; Kato, A; Adachi, I; Wang, X; Matsuya, Y; Sugimoto, K; Takemura, M; Endo, S; Matsunaga, T; Hara, A; Koseki, J; Narukawa, K; Hirono, S; Toyooka, N Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-ß-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1. Bioorg Med Chem 20:356-67 (2011) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B10
Synonyms:
AK1BA_HUMAN | AKR1B10 | AKR1B11 | ARL-1 | ARP | Aldo-keto reductase family 1 member B10 | Aldo-keto reductase family 1 member B10 (AKR1B10) | Aldo-keto reductase family member 1B10 (AKR1B10) | Aldose reductase-like | Aldose reductase-related protein | SI reductase | Small intestine reductase | hARP
Type:
Protein
Mol. Mass.:
36024.67
Organism:
Homo sapiens (Human)
Description:
O60218. 1ZUA; 4JII; 4GQ0
Residue:
316
Sequence:
MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPFNAEY
  
Inhibitor
Name:
BDBM50363056
Synonyms:
CHEMBL1946961
Type:
Small organic molecule
Emp. Form.:
C21H16F4N2O2S
Mol. Mass.:
436.423
SMILES:
OC(=O)Cn1c2c(CCN(Cc3ccc(cc3)C(F)(F)F)C2=S)c2cc(F)ccc12
Structure:
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