Target
Mitogen-activated protein kinase 10
Ligand
BDBM50363453
Substrate
n/a
Meas. Tech.
ChEMBL_800186 (CHEMBL1947748)
IC50
110±n/a nM
Citation
 Krenitsky, VPDelgado, MNadolny, LSahasrabudhe, KAyala, LClareen, SSHilgraf, RAlbers, RKois, AHughes, KWright, JNowakowski, JSudbeck, EGhosh, SBahmanyar, SChamberlain, PMuir, JCathers, BEGiegel, DXu, LCeleridad, MMoghaddam, MKhatsenko, OOmholt, PKatz, JPai, SFan, RTang, YShirley, MABenish, BBlease, KRaymon, HBhagwat, SHenderson, ICole, AGBennett, BSatoh, Y Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury. Bioorg Med Chem Lett 22:1427-32 (2012) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 10
Synonyms:
JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 | c-Jun N-terminal kinase 3 (JNK3)
Type:
Enzyme
Mol. Mass.:
52586.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
464
Sequence:
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
  
Inhibitor
Name:
BDBM50363453
Synonyms:
CHEMBL1946331
Type:
Small organic molecule
Emp. Form.:
C19H23FN6
Mol. Mass.:
354.4245
SMILES:
CC(C)Nc1ncc2nc(Nc3ccccc3F)n(C3CCCC3)c2n1
Structure:
Search PDB for entries with ligand similarity: