Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 9
Ligand
BDBM50363856
Substrate
n/a
Meas. Tech.
ChEMBL_802235 (CHEMBL1949393)
IC50
160000±n/a nM
Citation
 Wang, Q; Zhu, M; Zhu, R; Lu, L; Yuan, C; Xing, S; Fu, X; Mei, Y; Hang, Q Exploration ofa-aminophosphonate N-derivatives as novel, potent and selective inhibitors of protein tyrosine phosphatases. Eur J Med Chem 49:354-64 (2012) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 9
Synonyms:
3.1.3.48 | PTN9_HUMAN | PTP-MEG2 | PTPN9 | PTPase MEG2 | Protein-tyrosine phosphatase MEG2 | Protein-tyrosine phosphatase MEG2 (PTP-Meg2) | Tyrosine-protein phosphatase non-receptor type 9
Type:
n/a
Mol. Mass.:
68030.33
Organism:
Homo sapiens (Human)
Description:
P43378
Residue:
593
Sequence:
MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLRAIELFHSYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDPTGASIALFTARLHHPHKSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFPARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKTSEVTQHLPRECLPENLGGYVKIDLATWNFQFLPQVNGHPDPFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ
  
Inhibitor
Name:
BDBM50363856
Synonyms:
CHEMBL1946247
Type:
Small organic molecule
Emp. Form.:
C13H14NO5P
Mol. Mass.:
295.2277
SMILES:
Oc1ccc(N[C@H](c2ccccc2O)P(O)(O)=O)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: