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Target
Lipoprotein lipase
Ligand
BDBM50364281
Substrate
n/a
Meas. Tech.
ChEMBL_804416 (CHEMBL1954843)
IC50
9000±n/a nM
Citation
 O'Connell, DP; LeBlanc, DF; Cromley, D; Billheimer, J; Rader, DJ; Bachovchin, WW Design and synthesis of boronic acid inhibitors of endothelial lipase. Bioorg Med Chem Lett 22:1397-401 (2012) [PubMed]  Article 
Target
Name:
Lipoprotein lipase
Synonyms:
LIPD | LIPL_HUMAN | LPL
Type:
PROTEIN
Mol. Mass.:
53173.96
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1280894
Residue:
475
Sequence:
MESKALLVLTLAVWLQSLTASRGGVAAADQRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLNKKSG
  
Inhibitor
Name:
BDBM50364281
Synonyms:
CHEMBL1952294
Type:
Small organic molecule
Emp. Form.:
C8H11BO2
Mol. Mass.:
149.983
SMILES:
CCc1ccc(cc1)B(O)O
Structure:
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