Reaction Details Report a problem with these data
Target
Legumain
Ligand
BDBM50364368
Substrate
n/a
Meas. Tech.
ChEMBL_805028 (CHEMBL1952889)
IC50
8.6±n/a nM
Citation
 Lee, J; Bogyo, M Synthesis and evaluation of aza-peptidyl inhibitors of the lysosomal asparaginyl endopeptidase, legumain. Bioorg Med Chem Lett 22:1340-3 (2012) [PubMed]  Article 
Target
Name:
Legumain
Synonyms:
LGMN_MOUSE | Lgmn | Prsc1 | asparaginyl endopeptidase
Type:
PROTEIN
Mol. Mass.:
49370.42
Organism:
Mus musculus
Description:
n/a
Residue:
435
Sequence:
MTWRVAVLLSLVLGAGAVPVGVDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNGIPDEQIIVMMYDDIANSEENPTPGVVINRPNGTDVYKGVLKDYTGEDVTPENFLAVLRGDAEAVKGKGSGKVLKSGPRDHVFIYFTDHGATGILVFPNDDLHVKDLNKTIRYMYEHKMYQKMVFYIEACESGSMMNHLPDDINVYATTAANPKESSYACYYDEERGTYLGDWYSVNWMEDSDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKSISTMKVMQFQGMKHRASSPISLPPVTHLDLTPSPDVPLTILKRKLLRTNDVKESQNLIGQIQQFLDARHVIEKSVHKIVSLLAGFGETAERHLSERTMLTAHDCYQEAVTHFRTHCFNWHSVTYEHALRYLYVLANLCEAPYPIDRIEMAMDKVCLSHY
  
Inhibitor
Name:
BDBM50364368
Synonyms:
CHEMBL1950284
Type:
Small organic molecule
Emp. Form.:
C20H27N5O8
Mol. Mass.:
465.4571
SMILES:
CCOC(=O)C1OC1C(=O)N(CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC#C)NC(C)=O |r|
Structure:
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