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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50364541
Substrate
n/a
Meas. Tech.
ChEMBL_802831 (CHEMBL1953649)
EC50
9.7±n/a nM
Citation
 Semple, G; Lehmann, J; Wong, A; Ren, A; Bruce, M; Shin, YJ; Sage, CR; Morgan, M; Chen, WC; Sebring, K; Chu, ZL; Leonard, JN; Al-Shamma, H; Grottick, AJ; Du, F; Liang, Y; Demarest, K; Jones, RM Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile. Bioorg Med Chem Lett 22:1750-5 (2012) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50364541
Synonyms:
CHEMBL1951011
Type:
Small organic molecule
Emp. Form.:
C21H26FN3O6S
Mol. Mass.:
467.511
SMILES:
CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(cc2F)S(C)(=O)=O)c1C
Structure:
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