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Target
Lysosomal Pro-X carboxypeptidase
Ligand
BDBM50364684
Substrate
n/a
Meas. Tech.
ChEMBL_802882 (CHEMBL1953700)
IC50
1.1±n/a nM
Citation
 Shen, HC; Ding, FX; Jiang, J; Verras, A; Chabin, RM; Xu, S; Tong, X; Chen, Q; Xie, D; Lassman, ME; Bhatt, UR; Garcia-Calvo, MM; Geissler, W; Shen, Z; Murphy, BA; Gorski, JN; Wiltsie, J; SinhaRoy, R; Hale, JJ; Pinto, S; Shen, DM Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors. Bioorg Med Chem Lett 22:1550-6 (2012) [PubMed]  Article 
Target
Name:
Lysosomal Pro-X carboxypeptidase
Synonyms:
PCP_MOUSE | Prcp | Proline carboxypeptidase | Prolylcarboxypeptidase
Type:
PROTEIN
Mol. Mass.:
55028.96
Organism:
Mus musculus
Description:
ChEMBL_1335505
Residue:
491
Sequence:
MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGFADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGGMLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWNVIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLPAWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNIIFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMKKWILDFYSNIQ
  
Inhibitor
Name:
BDBM50364684
Synonyms:
CHEMBL1951473
Type:
Small organic molecule
Emp. Form.:
C24H22Cl2FN3O
Mol. Mass.:
458.355
SMILES:
CC(N1CCC2(CC1)OC(c1cccnc21)c1cc(Cl)cc(Cl)c1)c1ccc(F)cn1
Structure:
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