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Target
Histamine H3 receptor
Ligand
BDBM50365049
Substrate
n/a
Meas. Tech.
ChEMBL_804715 (CHEMBL1953342)
Ki
>3000±n/a nM
Citation
 Sundar, BG; Bailey, TR; Dunn, D; Hostetler, GA; Chatterjee, S; Bacon, ER; Yue, C; Schweizer, D; Aimone, LD; Gruner, JA; Lyons, J; Raddatz, R; Lesur, B Novel morpholine ketone analogs as potent histamine H3 receptor inverse agonists with wake activity. Bioorg Med Chem Lett 22:1546-9 (2012) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50365049
Synonyms:
CHEMBL1951058
Type:
Small organic molecule
Emp. Form.:
C21H32N2O4
Mol. Mass.:
376.4898
SMILES:
COC[C@@H]1CCCN1CCCOc1ccc(cc1)C(=O)CN1CCOCC1 |r|
Structure:
Search PDB for entries with ligand similarity: