Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50336977
Substrate
n/a
Meas. Tech.
ChEMBL_806479 (CHEMBL1959518)
Ki
24±n/a nM
Citation
 Baraldi, PG; Baraldi, S; Saponaro, G; Preti, D; Romagnoli, R; Piccagli, L; Cavalli, A; Recanatini, M; Moorman, AR; Zaid, AN; Varani, K; Borea, PA; Tabrizi, MA Novel 1,3-dipropyl-8-(3-benzimidazol-2-yl-methoxy-1-methylpyrazol-5-yl)xanthines as potent and selective A2B adenosine receptor antagonists. J Med Chem 55:797-811 (2012) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50336977
Synonyms:
CHEMBL1672627 | N-[5-(3-Fluoropyridin-4-yl)-6-pyridin-3-ylpyrazin-2-yl]cyclopropanecarboxamide
Type:
Small organic molecule
Emp. Form.:
C18H14FN5O
Mol. Mass.:
335.3351
SMILES:
Fc1cnccc1-c1ncc(NC(=O)C2CC2)nc1-c1cccnc1
Structure:
Search PDB for entries with ligand similarity: