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Target
Nuclear receptor subfamily 1 group D member 1
Ligand
BDBM50366238
Substrate
n/a
Meas. Tech.
ChEMBL_808916 (CHEMBL1961800)
IC50
710±n/a nM
Citation
 Solt, LA; Wang, Y; Banerjee, S; Hughes, T; Kojetin, DJ; Lundasen, T; Shin, Y; Liu, J; Cameron, MD; Noel, R; Yoo, SH; Takahashi, JS; Butler, AA; Kamenecka, TM; Burris, TP Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature 485:62-68 (2012) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 1 group D member 1
Synonyms:
EAR-1 | EAR1 | HREV | NR1D1 | NR1D1_HUMAN | Rev-erbA-alpha | THRAL | V-erbA-related protein 1
Type:
PROTEIN
Mol. Mass.:
66822.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_958222
Residue:
614
Sequence:
MTTLDSNNNTGGVITYIGSSGSSPSRTSPESLYSDNSNGSFQSLTQGCPTYFPPSPTGSLTQDPARSFGSIPPSLSDDGSPSSSSSSSSSSSSFYNGSPPGSLQVAMEDSSRVSPSKSTSNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQSAMNLANNQLSSQCPLETSPTQHPTPGPMGPSPPPAPVPSPLVGFSQFPQQLTPPRSPSPEPTVEDVISQVARAHREIFTYAHDKLGSSPGNFNANHASGSPPATTPHRWENQGCPPAPNDNNTLAAQRHNEALNGLRQAPSSYPPTWPPGPAHHSCHQSNSNGHRLCPTHVYAAPEGKAPANSPRQGNSKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMGMGDLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNRPLETSRFTKLLLKLPDLRTLNNMHSEKLLSFRVDAQ
  
Inhibitor
Name:
BDBM50366238
Synonyms:
CHEMBL1961796
Type:
Small organic molecule
Emp. Form.:
C20H24ClN3O4S
Mol. Mass.:
437.94
SMILES:
CCOC(=O)N1CCC(CN(Cc2ccc(s2)[N+]([O-])=O)Cc2ccc(Cl)cc2)C1
Structure:
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