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Target
Inositol polyphosphate-5-phosphatase A
Ligand
BDBM50279840
Substrate
n/a
Meas. Tech.
ChEBML_90117
Ki
26000±n/a nM
Citation
 Sawyer, DA; Potter, BV Total synthesis of L-2,2-difluoro-2-deoxy-MYO-inositol 1,4,5-trisphosphate, a potent inhibitor of the enzymes of d-MYO-inositol 1,4,5-trisphosphate metabolism Bioorg Med Chem Lett 1:705-710 (1991)    Article 
Target
Name:
Inositol polyphosphate-5-phosphatase A
Synonyms:
5PTASE | I5P1_HUMAN | INPP5A | Type I inositol-1,4,5-trisphosphate 5-phosphatase
Type:
PROTEIN
Mol. Mass.:
47823.52
Organism:
Homo sapiens (Human)
Description:
ChEMBL_4316
Residue:
412
Sequence:
MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQFDFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDLVNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSKSVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGTALLEFDKELSVFKDRLYELDISFPPSYPYSEDARQGEQYMNTRCPAWCDRILMSPSAKELVLRSESEEKVVTYDHIGPNVCMGDHKPVFLAFRIMPGAGKPHAHVHKCCVVQ
  
Inhibitor
Name:
BDBM50279840
Synonyms:
(D)-2,2-difluoro-2-deoxy-myo-inositol 1,4,5-triphosphate | (DL)-2,2-difluoro-2-deoxy-myo-inositol 1,4,5-triphosphate | (L)-2,2-difluoro-2-deoxy-myo-inositol 1,4,5-triphosphate | CHEMBL1161466
Type:
Small organic molecule
Emp. Form.:
C6H7F2O14P3
Mol. Mass.:
434.0328
SMILES:
OC1C(OP([O-])([O-])=O)C(OP([O-])([O-])=O)C(O)C(F)(F)C1OP([O-])([O-])=O
Structure:
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