Reaction Details Report a problem with these data
Target
Ribose-phosphate pyrophosphokinase 1
Ligand
BDBM50280244
Substrate
n/a
Meas. Tech.
ChEBML_156521
IC50
5100000±n/a nM
Citation
 Nave, J; Wolff-Kugel, D; Halazy, S Carbocyclic phosphonate analogs of 2,3-dideoxyadenosine-5-monophosphate as substrates of 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetate Bioorg Med Chem Lett 2:1483-1488 (1992)    Article 
Target
Name:
Ribose-phosphate pyrophosphokinase 1
Synonyms:
PRPS1 | PRPS1_HUMAN | Ribose-phosphate pyrophosphokinase I
Type:
PROTEIN
Mol. Mass.:
34836.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_156521
Residue:
318
Sequence:
MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL
  
Inhibitor
Name:
BDBM50280244
Synonyms:
Phosphoric acid mono-[(2R,3R,4S,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester
Type:
Small organic molecule
Emp. Form.:
C10H14N5O7P
Mol. Mass.:
347.2212
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@H](O)[C@@H]1O
Structure:
Search PDB for entries with ligand similarity: