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Target
Endothelin-converting enzyme 1
Ligand
BDBM50282595
Substrate
n/a
Meas. Tech.
ChEMBL_64216 (CHEMBL675453)
IC50
960±n/a nM
Citation
 Fukami, T; Hayama, T; Amano, Y; Nakamura, Y; Arai, Y; Matsuyama, K; Yano, M; Ishikawa, K Aminophosphonate endothelin converting enzyme inhibitors: potency-enhancing and selectivity-improving modifications of phosphoramidon Bioorg Med Chem Lett 4:1257-1262 (1994)    Article 
Target
Name:
Endothelin-converting enzyme 1
Synonyms:
ECE1 | ECE1_BOVIN
Type:
PROTEIN
Mol. Mass.:
85507.71
Organism:
Bos taurus
Description:
ChEMBL_64216
Residue:
754
Sequence:
MMSTYKRATLDEEDLVDSLSESDVYPNHLQVNFRGPRNGQRCWAARTPVEKRLVVLVALLAAALVACLAVLGIQYQTRTPSVCLSEACISVTSSILSSMDPTVDPCQDFFTYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELKAKPLMELIEKLGGWNITGPWDKDNFQDTLQVVTSHYHTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGAEDTIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVIYDKEYLSKVSTLINSTDKCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENTLGFALGPMFVKATFAEDSKNIASEIILEIKKAFEESLSTLKWMDEDTRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTACMVEQYGNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQTLPTLGLTNNQLFFLSFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSISNSKEFSEHFHCPPGSPMNPHHKCEVW
  
Inhibitor
Name:
BDBM50282595
Synonyms:
CHEMBL281562 | PO3 2-Leu-Trp-O-3K
Type:
Small organic molecule
Emp. Form.:
C17H21N3O6P
Mol. Mass.:
394.3405
SMILES:
CC(C)C[C@H](NP([O-])([O-])=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C([O-])=O
Structure:
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