Reaction Details Report a problem with these data
Target
Endothelin-converting enzyme 1
Ligand
BDBM50282593
Substrate
n/a
Meas. Tech.
ChEMBL_64216 (CHEMBL675453)
IC50
260±n/a nM
Citation
Fukami, T; Hayama, T; Amano, Y; Nakamura, Y; Arai, Y; Matsuyama, K; Yano, M; Ishikawa, K Aminophosphonate endothelin converting enzyme inhibitors: potency-enhancing and selectivity-improving modifications of phosphoramidon Bioorg Med Chem Lett 4:1257-1262 (1994) Article
More Info.:
Target
Name:
Endothelin-converting enzyme 1
Synonyms:
ECE1 | ECE1_BOVIN
Type:
PROTEIN
Mol. Mass.:
85507.71
Organism:
Bos taurus
Description:
ChEMBL_64216
Residue:
754
Sequence:
MMSTYKRATLDEEDLVDSLSESDVYPNHLQVNFRGPRNGQRCWAARTPVEKRLVVLVALLAAALVACLAVLGIQYQTRTPSVCLSEACISVTSSILSSMDPTVDPCQDFFTYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELKAKPLMELIEKLGGWNITGPWDKDNFQDTLQVVTSHYHTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGAEDTIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVIYDKEYLSKVSTLINSTDKCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENTLGFALGPMFVKATFAEDSKNIASEIILEIKKAFEESLSTLKWMDEDTRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTACMVEQYGNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQTLPTLGLTNNQLFFLSFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSISNSKEFSEHFHCPPGSPMNPHHKCEVW
Inhibitor
Name:
BDBM50282593
Synonyms:
3-(S)-1H-Indol-3-yl-2-[(S)-4-methyl-2-(3-naphthalen-1-yl-1-phosphono-propylamino)-pentanoylamino]-propionic acid | CHEMBL25269
Type:
Small organic molecule
Emp. Form.:
C30H36N3O6P
Mol. Mass.:
565.5971
SMILES:
CC(C)C[C@H](NC(CCc1cccc2ccccc12)P(O)(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O