Reaction Details Report a problem with these data
Target
Endothelin receptor type B
Ligand
BDBM50284775
Substrate
n/a
Meas. Tech.
ChEBML_63879
IC50
2.5±n/a nM
Citation
 Fukami, T; Yamakawa, T; Kojima, H; Amano, Y; Ihara, M; Yano, M; Ishikawa, K Synthesis of 2-substituted d-tryptophan-containing peptide derivatives with endothelin receptor antagonist activity Bioorg Med Chem Lett 5:1483-1488 (1995)    Article 
Target
Name:
Endothelin receptor type B
Synonyms:
EDNRB | EDNRB_PIG | Endothelin receptor ET-B
Type:
PROTEIN
Mol. Mass.:
49616.89
Organism:
Sus scrofa
Description:
ChEMBL_63872
Residue:
443
Sequence:
MQPLRSLCGRALVALIFACGVAGVQSEERGFPPAGATPPALRTGEIVAPPTKTFWPRGSNASLPRSSSPPQMPKGGRMAGPPARTLTPPPCEGPIEIKDTFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEALGFDMITTDYKGNRLRICLLHPTQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQNDSNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
  
Inhibitor
Name:
BDBM50284775
Synonyms:
(S)-2-((R)-3-(2-Bromo-1H-indol-3-yl)-2-{2-[((2R,6S)-2,6-dimethyl-piperidine-1-carbonyl)-amino]-4-methyl-pentanoylamino}-propionylamino)-hexanoic acid | CHEMBL289349
Type:
Small organic molecule
Emp. Form.:
C31H46BrN5O5
Mol. Mass.:
648.631
SMILES:
CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(O)=O
Structure:
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