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Target
HLA class II histocompatibility antigen, DR beta 3 chain
Ligand
BDBM50287654
Substrate
n/a
Meas. Tech.
ChEBML_47860
IC50
23300±n/a nM
Citation
 Hanson, GJ; Vuletich, JL; Bedell, LJ; Bono, CP; Howard, SC; Welply, JK; Woulfe, SL; Zacheis, ML Design of MHC class II (DR4) ligands using conformationally restricted imino acids at p3 and p5 Bioorg Med Chem Lett 6:1931-1936 (1996)    Article 
Target
Name:
HLA class II histocompatibility antigen, DR beta 3 chain
Synonyms:
DRB3_HUMAN | HLA class II histocompatibility antigen DRB3-1 | HLA class II histocompatibility antigen, DRB3-1 beta chain | HLA-DRB3 | Human leukocyte antigen DR beta chain | MHC class I antigen DRB3*1
Type:
PROTEIN
Mol. Mass.:
29969.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_47860
Residue:
266
Sequence:
MVCLKLPGGSSLAALTVTLMVLSSRLAFAGDTRPRFLELRKSECHFFNGTERVRYLDRYFHNQEEFLRFDSDVGEYRAVTELGRPVAESWNSQKDLLEQKRGRVDNYCRHNYGVGESFTVQRRVHPQVTVYPAKTQPLQHHNLLVCSVSGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSALTVEWRARSESAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS
  
Inhibitor
Name:
BDBM50287654
Synonyms:
(S)-4-((S)-2-Carbamoyl-pyrrolidin-1-yl)-3-({1-[(S)-2-((R)-3-cyclohexyl-butyrylamino)-3-methyl-butyryl]-piperidine-2-carbonyl}-amino)-4-oxo-butyric acid | CHEMBL2373020
Type:
Small organic molecule
Emp. Form.:
C30H49N5O7
Mol. Mass.:
591.7394
SMILES:
CC(C)[C@H](NC(=O)C[C@H](C)C1CCCCC1)C(=O)N1CCCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(N)=O
Structure:
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