Reaction Details Report a problem with these data
Target
Neuraminidase
Ligand
BDBM4941
Substrate
n/a
Meas. Tech.
ChEBML_200650
IC50
400±n/a nM
Citation
Smith, PW; Sollis, SL; Howes, PD; Cherry, PC; Cobley, KN; Taylor, H; Whittington, AR; Scicinski, J; Bethell, RC; Taylor, N; Skarzynski, T; Cleasby, A; Singh, O; Wonacott, A; Varghese, J; Colman, P Novel inhibitors of influenza sialidases related to GG167 structure-activity, crystallographic and Molecular dynamics studies with 4H-pyran-2-carboxylic acid 6-carboxamides Bioorg Med Chem Lett 6:2931-2936 (1996) Article
More Info.:
Target
Name:
Neuraminidase
Synonyms:
Influenza B Virus Neuraminidase | NA | NRAM_INBLE | Neuraminidase | Neuraminidase B
Type:
Enzyme
Mol. Mass.:
51446.67
Organism:
Influenza B virus (B/Lee/40)
Description:
n/a
Residue:
466
Sequence:
MLPSTVQTLTLLLTSGGVLLSLYVSASLSYLLYSDVLLKFSSTKTTAPTMSLECTNASNAQTVNHSATKEMTFPPPEPEWTYPRLSCQGSTFQKALLISPHRFGEIKGNSAPLIIREPFVACGPKECRHFALTHYAAQPGGYYNGTRKDRNKLRHLVSVKLGKIPTVENSIFHMAAWSGSACHDGREWTYIGVDGPDNDALVKIKYGEAYTDTYHSYAHNILRTQESACNCIGGDCYLMITDGSASGISKCRFLKIREGRIIKEILPTGRVEHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTKTYLDTPRPDDGSIAGPCESNGDKWLGGIKGGFVHQRMASKIGRWYSRTMSKTNRMGMELYVKYDGDPWTDSDALTLSGVMVSIEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKDTWHSAATAIYCLMGSGQLLWDTVTGVDMAL
Inhibitor
Name:
BDBM4941
Synonyms:
(2R,3R,4S)-4-amino-3-acetamido-2-[ethyl(propyl)carbamoyl]-3,4-dihydro-2H-pyran-6-carboxylic acid | carboxamide deriv. 4m
Type:
Small organic molecule
Emp. Form.:
C14H23N3O5
Mol. Mass.:
313.3495
SMILES:
[H][C@]1(OC(=C[C@H](N)[C@H]1NC(C)=O)C(O)=O)C(=O)N(CC)CCC |r,c:3|