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Target
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Ligand
BDBM50366474
Substrate
n/a
Meas. Tech.
ChEBML_161425
IC50
70000±n/a nM
Citation
 McCluskey, A; Taylor, C; Quinn, RJ; Suganuma, M; Fujiki, H Inhibition of protein phosphatase 2A by cantharidin analogues Bioorg Med Chem Lett 6:1025-1028 (1996)    Article 
Target
Name:
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Synonyms:
2AAA_MOUSE | Ppp2r1a | Serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform
Type:
PROTEIN
Mol. Mass.:
65303.23
Organism:
Mus musculus
Description:
ChEMBL_161425
Residue:
589
Sequence:
MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMTQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA
  
Inhibitor
Name:
BDBM50366474
Synonyms:
NORCANTHARIDIN
Type:
Small organic molecule
Emp. Form.:
C8H8O4
Mol. Mass.:
168.1467
SMILES:
O=C1OC(=O)[C@@H]2[C@H]3CC[C@@H](O3)[C@H]12 |r,TLB:1:11:8.7:10,THB:3:5:8.7:10|
Structure:
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