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Target
D(2) dopamine receptor
Ligand
BDBM50290216
Substrate
n/a
Meas. Tech.
ChEBML_58455
Ki
10±n/a nM
Citation
 Belliotti, TR; Kesten, SR; Rubin, JR; Wustrow, DJ; Georgic, LM; Zoski, KT; Akunne, HC; Wise, LD Novel cyclohexyl amides as potent and selective D3 dopamine receptor ligands Bioorg Med Chem Lett 7:2403-2408 (1997)    Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50290216
Synonyms:
5-Methyl-thiophene-2-carboxylic acid (4-{2-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-ethyl}-cyclohexyl)-amide | CHEMBL76908
Type:
Small organic molecule
Emp. Form.:
C24H31Cl2N3OS
Mol. Mass.:
480.493
SMILES:
Cc1ccc(s1)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(Cl)c2Cl)CC1 |wU:12.13,wD:9.9,(7.77,-13.63,;6.28,-13.21,;5.18,-14.26,;3.34,-12.35,;4.44,-11.29,;5.93,-11.7,;3.67,-9.95,;2.13,-9.96,;4.44,-8.62,;5.98,-8.62,;6.75,-9.95,;8.29,-9.94,;9.06,-8.61,;10.6,-8.59,;11.37,-7.26,;12.91,-7.23,;13.7,-8.54,;15.24,-8.5,;15.98,-7.17,;15.2,-5.86,;13.66,-5.89,;17.52,-7.14,;18.32,-8.45,;19.86,-8.43,;20.6,-7.08,;19.79,-5.75,;20.53,-4.39,;18.25,-5.79,;17.46,-4.48,;8.28,-7.28,;6.74,-7.29,)|
Structure:
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